Topical Retinoids and Benzoyl Peroxide Together

A recent study published in Cosmetic Dermatology took a look at using topical retinoids and benzoyl peroxide together (at the same time) in the treatment of acne.

In the past, the original topical reitnoid, tretinoin (Retin-a) was not stable and would lose its ability to work when combined with other acne products. More recently, newer topical retinoids such as adapalene (Differin) and the microsphere formulation of tretinoin (Retin-a Microgel) have shown better stability when used with other agents such as benzoyl peroxide.

The study made reference to tests that had been done that showed that Differin is 100% stable after 24 hours of being mixed with benzoyl peroxide and that Retin-a microgel was stable to 97% at 8 hours and 70% after 24 hours of being mixed with benzoyl peroxide.

The study’s main evaluation was on how this combination was tolerated and it proved that the combination of both agents was no more irritating than the topical retinoid alone.

The study conclusions showed that the use of either topical retinoid along with the benzoyl peroxide (which was the Triaz 3% pad) proved to be both stable and well tolerated. What this suggests is that this combination being used at the same time may make treatment easier to do and thus increase overall compliace and results. The study did not compare how well the combination worked in treating the acne, but we’re sure more data will be available on this in the future.

Add comment February 14th, 2006