Refrigeration Issues

We are often asked whether some of the topical acne medications require refrigeration. The main topical acne medications that we focus on for this issue are the combination medications. In the past, the original combination medication Benzamycin did (and still does) require refrigeration. This is so the two ingredients do not “come apart.” More recently, the newer combination medications which combine the effects of topical clindamycin and benzoyl peroxide (Benzaclin gel and Duac gel) do not require refrigeration. This allows for added convenience and ease of use.

When comparing the two products, Benzaclin gel is stable without refrigeration for up to 13 weeks after being mixed at the pharmacy and Duac gel is stable for 8 weeks after being mixed at the manufacturer. So, while Benzaclin is stable for longer, both will give you at least two months of use before expiring.

Add comment December 15th, 2005